PURPURA

DOC I HAVE PURPURA

Purpura is a physical sign of escape of red blood cells through the endometrial wall of the dermal capillaries resulting in purplish blotches under the skin.

What is the cause of Purpura?

It is usually due to vacular wall defect, low platelets, infections or injury:

Vascular wall defect may be caused by:
1.Scurvy or lack of vitamin C
2.Fragilty of vascular wall due to age(senile purpura, anemia, diabetes or steroid therapy
3.Autoimmune disease such as Henoch Schonlein purpura
4.Blood cancer such as multiple myeloma

Infections:
1.Dengue fever - cause low platelets
2.Subacute bacterial endocarditis - cause low platelets
3.Typhoid fever
4.Rocky mountain fever

Low Platelets:
1.Aplastic anemia - low production of red blood cells, white blood cells and platelets from marrow
2.Megaloblastic anemia
3.Leukemia
4.Exposure to toxic drugs (chemotherapy) or radiation
5.Splenomegaly
6.Idiopathic thrombocytopenic purpura
7.Lymphoma
8.Neonatal thromocytopenia
9.Drug induced thrombocytopenia

Others:
1.Injury
2.Trauma
3.Burns
4.Dialysis
5.Blood thinners such as aspirin, warfarin, plavix
3.alcohol

What are the symptoms of Purpura?

Symptoms:

1.typical purple blotches under the skin
2.fever with purpura is a medical emergency
3.fundoscopic bleeding
4.abdominal pain may be a recurring symptom
5.splenomegaly
6.low platelets
7.bleeding time prolonged

How do you made the diagnosis of Purpura?

Diagnosis of Purpura is often based on
1. history of Purpura
2. history of drug allergy
3. history of blood thinners
4. Full blood count
5. Bone marrow biopsy

What are the complications of Purpura?

The complications of Purpura are:

1. Anemia

2. damage to liver , spleen and nerves

What is the treatment of Purpura?

Treat the underlying cause:
1.Blood transfusion of platelets in severe cases

2.Antibiotics for infections

3.Avoid causative agents especially drugs, vitamin deficiency,renal disease,radiation

4.corticosteroids is useful in idiopathic thrombocytopenic purpura

5.Splenectomy may be helpful

What is the prognosis of Purpura?

Prognosis depends on the cause of Purpura.
Patients with blood cancer has a poorer prognosis compared to injury.

A Family Doctor's Tale - HENOCH-SCHONLEIN PURPURA

DOC I HAVE HENOCH-SCHONLEIN PURPURA

Henoch-Schonlein Purpura is a bleeding disease where small blood vessels become fragile and allow blood to leak from them.

Bleeding into the skin give rise to a typical rash called purpura like a bruise while bleeding into the joints, kidneys or digestive tract can cause damage to these organs.

People of all ages are affected .

It is more common in children between the age of 2 to 10 years.

The cause is unknown but believed to be an allergic reaction to something or a bacterial infection (suspected streptococcus)

Symptoms of Henoch-Schonlein Purpura are:
1.rash is pink, red or purplish blood filled spots that do not fade
when pressed

2.the rash appears first on the buttocks and the back of arms and body especially around the ankles and elbows then spread to the front of the limbs.

3.joint pain and swelling

4.abdominal pain in many cases with vomiting and diarrhea

5.blood in the stools or urine

Diagnosis of Henoch-Schonlein Purpura is by:
1.The typical rash and its location can suggest the diagnosis of Henoch-Schonlein Purpura

2.Blood and urine tests may be done to rule out other causes and to exclude any kidney inflammation.

Blood and protein in the urine may suggest kidney involvement.

3.Abdominal X-ray may be needed if there is abdominal pain and vomiting

4.Ultrasound of kidney may also be needed for exclusion of serious kidney involvement.

Complications of Henoch-Schonlein Purpura are:
1.inflammation of the kidneys

2.joint arthritis due to bleeding in the joint

Treatment of Henoch-Schonlein Purpura:
No treatment may be needed if the condition or symptoms are mild.

For moderate or severe cases:
1. Bed rest is important

2. paracetamol for pain or fever

3. corticosteroids are needed as treatment for allergy

4. antibiotics are given if there is a bacterial infection.

Prognosis of Henoch-Schonlein Purpura is:
The illness may last a few days to a month during which the symptoms may recur.

Most patients make a full recovery and there is no long term ill effects.

In most cases inflammation of the kidneys disappears in a few days but in some patient recovery from the kidney inflammation may take up to 2 years.