AGING

DOC I AM AGING

Aging is the process where the human body accumulate damage to its cells. tissues and organs as it grows older.

This accumulated damage is believed to be the result of oxidation damage to the cell contents from free radicals.

Average and maximum lifespans:
The maximum life span for humans is currently maximized at approximately 120 years
Average lifespan in a population is lowered:
1.infant and child mortality is frequently linked to infectious diseases or nutrition problems.

2.accidents and age-related chronic disease such as cancer or cardiovascular disease play an increasing role in mortality.

 Extension of lifespan can often be achieved by:
1.improved medical care,
2.vaccinations,
3.good diet,
4.exercise
5.avoidance of bad habits such as smoking.

Maximum lifespan is determined by
1.the rate of aging inherent in its genes and by environmental factors.
2.calorie restriction.
3.breeding from only older members.

Anti-aging medicine is the study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan.

In Theory extension of maximum lifespan could be achieved by
1. reducing the rate of aging damage,
2. periodic replacement of damaged tissues,
3. molecular repair or rejuvenation of deteriorated cells and tissues
4. enhancement of telomerase enzyme activity.

 Diets and supplements
1.nutrition—diets or supplements—as a means to extend lifespan
2.antioxidant supplements, such as Vitamin C, Vitamin E, Q10, lipoic acid, carnosine, and N-acetylcysteine, may extend life if the free radical theory of extending life is to be believed
3.oxytocin, insulin, human chorionic gonadotropin (hCG), and erythropoietin (EPO).
4.Resveratrol is a sirtuin stimulant that appears to extend lifespan in simple organisms

Hormone treatments
1.low-dose GH treatment for adults with GH deficiency changes the body composition by
a.increasing muscle mass, decreasing fat mass,
b.increasing bone density and muscle strength,
c.improves cardiovascular parameters (i.e. decrease of LDL cholesterol)
d.affects the quality of life without significant side effects.

Nanotechnology
nanomedicine could give rise to life extension through the repair of many processes thought to be responsible for aging.

Cloning and body part replacement
therapeutic cloning and stem cell research could one day provide a way to generate cells, body parts, or even entire bodies  that would be genetically identical to a prospective patient.

Cryonics
1.storing the body at low temperatures after death may provide an entry into a future in which advanced medical technologies may allow resuscitation and repair.
2.cryogenic temperatures will minimize changes in biological tissue for many years, giving the medical community ample time to cure all disease, rejuvenate the aged and repair any damage that is caused by the cryopreservation process.

Strategies for Engineered Negligible Senescence (SENS)
combine existing and predicted future biochemical and genetic techniques to a cure for cancer, stem cell treatments, addition of new enzymes to the human body and moving mitochondrial DNA to the cellular nucleus.

Genetic modification
artificial genes are integrated with an organism to replace mutated or otherwise deficient genes,
Targeting catalase to the mitochondria resulted in a 20% lifespan increase in mice, and improved performance in therapeutically infected mice.

Fooling genes
an approach to life-extension that involves fooling genes into thinking the body is young
The basic idea is that our bodies are composed of genes that activate throughout our lifetimes, some when we are young, and others when we are older.
These genes are activated by environmental factors and the changes caused by these genes activating can be fatal.

A Simple Guide to Osteoporosis

A Simple Guide to Osteoporosis
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What is Osteoporosis?
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Osteoporosis, which literally means porous bones, is a condition in which the bones become weak and brittle, resulting in a greater likelihood of breaking after minor trauma.
Bone is constantly being removed and replaced in our body.
Osteoporosis occurs when bone is lost faster than it can be replaced.

What are the symptoms of Osteoporosis?
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Osteoporosis is a silent disease. People with osteoporosis often do not know that they have the condition. Fractures from osteoporosis commonly occur in the wrist, spine and hip.
Persons with hip fractures suffers considerable loss of function and becomes dependent on others.

What are the risk factors of developing Osteoporosis?
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Factors that will increase the risk of developing osteoporosis are:
Female gender;
Caucasian or Asian race;
Thin and small body frames;
Family history of osteoporosis ;
Personal history of fracture as an adult;
Cigarette smoking ;
Excessive alcohol consumption;
Lack of exercise;
Diet low in calcium;
Poor nutrition and poor general health;
Malabsorption syndromes(nutrients poorly absorbed from the gastrointestinal system)
Low estrogen levels (such as occur in menopause or early surgical removal of both ovaries); Chemotherapy can cause early menopause due to its toxic effects on the ovaries;
Amenorrhea (loss of menstrual period) in young women causes low estrogen and osteoporosis;
Chronic inflammation, due to diseases (such as rheumatoid arthritis,chronic liver diseases);
Immobility, such as after a stroke, or from any condition that interferes with walking;
Hyperthyroidism, a condition with too much thyroid hormone ;
Hyperparathyroidism, a disease with excessive parathyroid hormone. In untreated hyperparathyroidism, excessive parathyroid hormone causes too much calcium to be removed from the bone, which can lead to osteoporosis;
Vitamin D deficiency. When vitamin D is lacking, the body cannot absorb adequate amounts of calcium to prevent osteoporosis.
Certain medications can cause osteoporosis. These include long-term use of heparin (a blood thinner), anti-seizure medications phenytoin (Dilantin) and phenobarbital, and long term use of oral corticosteroids (such as Prednisone).

How do you Screen for Osteoporosis?
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Bone Mineral Density:
Routine X-rays cannot detect osteoporosis until it is quite advanced and there is a lot of bone loss.
The best way to detect osteoporosis is to carry out a Bone Mineral Density (BMD) test to measure density (solidness) at various sites (e.g. hip, spine).
It will help to assess your risk of having a fracture.
BMD is frequently measured by dual energy X-ray absorptiometry (DXA).
It is a painless procedure.

How is osteoporosis diagnosed?
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A routine x-ray can reveal osteoporosis of the bone, which appears much thinner and lighter than normal bones. Unfortunately, by the time x-rays can detect osteoporosis, at least 30% of the bone has already been lost.
DXA measures bone density in the hip and the spine. The test takes only 5 to 15 minutes to perform, uses very little radiation and is quite precise.

Who should have bone density testing?
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All postmenopausal women below age 65 who have risk factors for osteoporosis;
All women aged 65 and older;

What are the consequences of Osteoporosis?
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Osteoporosis bone fractures are responsible for considerable pain, decreased quality of life, lost workdays, and disability.
Elderly patients can further develop pneumonia and blood clots in the leg veins that can travel to the lungs (pulmonary embolism) due to prolonged bed rest after a hip fracture.
Some 20% of women with a hip fracture will die in the subsequent year as an indirect result of the fracture.

How is osteoporosis treated and prevented?
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The purpose of osteoporosis treatment is the prevention of bone fractures by stopping bone loss and by increasing bone density and strength.
Early detection and timely treatment of osteoporosis can substantially decrease the risk of future fracture.
There is no complete cure for osteoporosis .
There is no way to completely rebuild bone that has been weakened by osteoporosis.
Therefore, prevention of osteoporosis is as important as treatment.

Osteoporosis treatment and prevention measures are:
Lifestyle Changes:
1.Exercise has a wide variety of beneficial health effects especially weight-bearing exercise, such as walking.
However, exercise does not bring about substantial increases in bone density.
The benefit of exercise for osteoporosis has mostly to do with decreasing the risk of falls, probably because balance is improved and/or muscle strength is increased.
It is important to avoid exercises that can injure already weakened bones.
In patients over 40 and those with heart disease, obesity, diabetes mellitus, and high blood pressure , exercise should be monitored.
Cessation of Smoking :Smoking cigarettes decreases estrogen levels and can lead to bone loss in women before menopause.
Decrease regular consumption of alcohol and caffeine on osteoporosis is not as clear as with exercise and cigarette.

Medications:
1.Medications that stop bone loss and increase bone strength, such as
alendronate (Fosamax),
risedronate (Actonel),
raloxifene (Evista),
ibandronate (Boniva),
calcitonin (Calcimar);
2.Medications that increase bone formation such as teriparatide (Forteo).
3..Calcium Supplements
Building strong and healthy bones requires an adequate dietary intake of calcium and exercise beginning in childhood and adolescence for both sexes.
800 mg/day for children ages 1 to 10
1000 mg/day for men, premenopausal women, and postmenopausal women also taking estrogen
1200 mg/day for teenagers and young adults ages 11 to 24
1500 mg/day for post menopausal women not taking estrogen 1200mg to 1500 mg/day for pregnant and nursing mothers
The total daily intake of calcium should not exceed 2000 mg
Daily calcium intake can be calculated by the following method:
Excluding dairy products, the average diet contains approximately 250 mg of calcium;
There is approximately 300 mg of calcium in an 8-ounce glass of milk;
There is approximately 450 mg of calcium in 8 ounces of plain yogurt;
There is approximately 1300 mg of calcium in 1 cup of cottage cheese;
There is approximately 200 mg of calcium in 1 ounce of cheddar cheese;
There is approximately 90 mg of calcium in ½ cup of vanilla ice cream;
There is approximately 300 mg of calcium in 8 ounces of calcium-fortified orange juice.
Additional calcium can be obtained by drinking more milk and eating more yogurt or cottage cheese, or by taking calcium supplement tablets as well from calcium-fortified foods.
Calcium supplements are safe and generally well tolerated.
Side effects are indigestion and constipation.
4.Vitamin D:
Vitamin D is important in several respects:
Vitamin D helps the absorption of calcium from the intestines.
A lack of vitamin D causes calcium-depleted bone (osteomalacia), which further weakens the bones and increases the risk of fractures.
Vitamin D, along with adequate calcium (1200 mg of elemental calcium), has been shown in some studies to increase bone density and decrease fractures in older postmenopausal, but not in premenopausal or perimenopausal women.
Vitamin D comes from the diet and the skin. Vitamin D production by the skin is dependent on exposure to sunlight. Daily Vitamin D intake are:
200 IU daily for men and women 19 to 50 years old,
400 IU daily for men and women 51 to 70 years old, and
600 IU daily for men and women 71 years and older.
But if a person already has osteoporosis, it is advisable to ensure 400 IU twice per day as usual daily intake, most commonly as a supplement alongside prescription osteoporosis medication.
5.Hormone therapy (menopausal hormone therapy)
Menopausal hormone therapy (previously referred to as hormone replacement therapy or HRT) has been shown to prevent bone loss, increase bone density, and prevent bone fractures. It is useful in preventing osteoporosis in postmenopausal women.
Medications that prevent bone loss and breakdown

How do you monitor Osteoporosis?
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Repeat bone density testing (DXA scans) is NOT indicated in monitoring osteoporosis treatment or prevention on a routine basis.
Bone density changes so slowly with treatment that the changes are smaller than the measurement error of the machine.
The real purpose of osteoporosis treatment is to decrease future bone fractures.
There is no good correlation between increases in bone density with decreases in fracture risks with treatment.
In the future, however, if ongoing research brings new technology or new therapies, testing decisions will clearly change.


Added 4th October 2008
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Osteoporosis
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One way of determining the risk of Osteoporosis:
substract the weight in kg from the age in years.

If the number is less than 0 the risk is low

If the number is between 0-20 the risk is moderate

If the number is above 20 the risk is high and you should see the doctor.